HORDB

ID: hor005726
Uniprot ID: P33689
Protein name: Neuropeptide Y
Gene name: npy
Organism: Xenopus laevis (African clawed frog)
Family: NPY family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Xenopus (subgenus), Xenopus (genus), Xenopodinae (subfamily), Pipidae (family), Pipoidea (superfamily), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region; GO:0031410 cytoplasmic vesicle; GO:0098992 neuronal dense core vesicle

Sequence: YPSKPDNPGEDAPAEDMAKYYSALRHYINLITRQRY
Length: 36
Propeptide: MQGNMRLWMSVLTLCLSMLICLGTFAEAYPSKPDNPGEDAPAEDMAKYYSALRHYINLITRQRYGKRSSPETMLSDVWWRENTENIPRSRFEDPPMW
Signal peptide: MQGNMRLWMSVLTLCLSMLICLGTFAEA
Modification: T36 Tyrosine amide
Glycosylation: NA
Mutagenesis: NA

Function: NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor005726_AF2.pdb

hor005726_ESM.pdb

Mass:	486917	Formula:	C189H284N52O58S
Absent amino acids:	CFVW	Common amino acids:	Y
pI:	7.51	Basic residues:	6
Polar residues:	11	Hydrophobic residues:	8
Hydrophobicity:	-117.78	Boman Index:	-9898
Half-Life:	2.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	2 min	Aliphatic Index	54.44
Instability Index:	6583.33	Extinction Coefficient cystines:	7450
Absorbance 280nm:	212.86